It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine kinase activity.

This protein is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking.

Mouse studies suggested an essential role of this protein in spermatogenesis.

[6] Loss of LMTK2 has been implicated to play a role in development of prostate cancer.

[8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.