It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs.

Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells.

It may also have a role in inducing differentiation in neuronal cells.

[7][8] Its suppressive role on melanoma development has been reported recently.

[9] AATK is thought to indirectly inhibit the SPAK/WNK4 activation of the Na-K-Cl cotransporter.