It serves the Jacksonville Transportation Authority (JTA) bus system, the First Coast Flyer bus rapid transit (BRT) system, and the Jacksonville Skyway monorail, as well as home to JTA's administrative offices.

It is across the street form the Prime F. Osborn III Convention Center and connected to by a pedestrian bridge to the Intercity Bus Terminal which is served by Greyhound Lines, Megabus, and RedCoach.

LaVilla station was one of the three original Jacksonville Skyway stops that opened with the initial 0.7-mile (1.1 km) Phase I-A segment in June 1989.

[1] In May 2017, JTA announced that the station would be closed about two months later for the construction of the Jacksonville Regional Transportation Center (JRTC).

[6] Brightline is an inter-city passenger rail system between Miami and West Palm Beach with an under-construction extension to Orlando.