La Guardia is a fishing and tourist community on the northwest coast of Isla Margarita, Venezuela.

La Guardia lies at the eastern end of a bar, or strip of land, that stretches more than 15 miles (24 km) from the main island of Margarita to Punta Tigre on the Macanao Peninsula, running between the Laguna de la Restinga and the Caribbean Sea.

José de Matos y Rabel was appointed Governor of Margarita on 5 July 1764 and took office on 3 January 1765.

On 21 July 1765 he mentioned in a letter to the King of Spain that he had installed two guards at the location to protect the island from smuggling, and this is the origin of the current name.

On 16 July each year the fishermen observe the day of the Virgen del Carmen, carrying her image in the long procession along the length of the bay.