La Penne-sur-Huveaune (French pronunciation: [la pɛn syʁ yvon], literally La Penne on Huveaune; Provençal: La Pena d’Evèuna) is a commune east of Marseille and west of Aubagne along the A50 autoroute in the department of Bouches-du-Rhône in the Provence-Alpes-Côte d'Azur region in southern France.

The river Huveaune flows through it, from which the commune derived its name.

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