Its faculty then included veteran educators Rosario Tsukimata (an affiliated Member of the Brothers), Pedro Generalao (founding Principal of Iligan City High School), Felicito Rugay (founding Director-Principal of Andres Soriano Memorial School, Lutopan, Cebu and Tranquilino Valderama Memorial School, Bubunawan, Bukidnon; and the Andres Soriano Jr. Learning Center, Aroroy, Masbate); and Carmelito Silva.

A need for a bigger campus due to a growing student population necessitated the purchase of a three-hectare lot in Pala-o belonging to the estate of Pedro Nuñez.

Honorius Alfred Shields, FSC, the second director and co-author of the book Biology for the Philippine High Schools, supervised the transfer to the nipa and bamboo structures and then, the construction of the permanent buildings in 1961.

It was arranged with the RVM Sisters that lower-grades boys and girls would study at St. Michael's College grade (elementary) school.

It was finally registered with the Securities and Exchange Commission by 1975 with the late EnManuel Hamoy as its first president and chairman of the board.

However, among the Brothers there was a worldwide movement towards the return of the charism of its founder, St. John Baptist De La Salle.

Then, the board of trustees approved the opening of the Night High School to begin operating in June 1994.

Jimmy Dalumpines FSC as its president (1988–99), a property in Agad-agad was purchased for the school's Recollection program and its commitment to be "earth-keepers" by developing it into an Ecology Sanctuary.

In 2000, the Brothers bought a property in Binuni, Bacolod, Lanao del Norte and asked the school's Community Development Office to help organize a cooperative similar to that of LAFAMCO.

This is to widen the opportunity for a free Lasallian education to qualified but economically disadvantaged youth of Mindanao particularly in Iligan City.

Through these services, Lasallians can receive updates regarding the school, share ideas and perspectives, and post photos making it more responsive to the demands of a technologically driven audience.

The PAASCU accreditors granted the high school a 5-year clean accreditation during the resurvey visit on November 26–27, 2007, in S.Y.

The move to use the new framework was deemed necessary to address the concern of improving the quality of education in the school and the country.

With La Salle Academy's vision to be the center of excellence in providing quality education to the youth, it required the teachers to continue attending seminar workshops on UbD to fully implement it in the classroom.

Having managed La Salle Green Hills for 10 years, he has planned improvements in the school such as infrastructures in preparation for the implementation of the K to 12 curriculum.

In SY 2015 – 2016, LSA received its Provisional Permit from the Department of Education allowing the school to start the Senior High School level with the following tracks: Academic Tracks – Accounting, Business and Management Strand (ABM), Humanities and Social Sciences Strand (HUMSS), Science, Technology, Engineering and Mathematics Strand (STEM) and Technical-Vocational Track with specialization in Electrical Installation and Maintenance and Computer Systems Servicing.

To prepare for its implementation, the school conducted a series of meetings with parents, students and partner industries.

These include the construction of new offices in the St. La Salle building, a covered walkway leading to the new property, and a satellite canteen.

In School Year 2018-2019, La Salle Academy marked its 60th year in Iligan City and Northern Mindanao, adopting the theme “Refining the Diamond Within through Lasallian Excellence.” The celebration included a kick-off event in June 2018 and SikSixty, a production prepared by the employees in March 2019.

All Lasallian schools around the country were invited to participate in the commemoration by De La Salle Philippines through a variety of events, including the Youth Sojourn, the Tour of the Relic of St. John Baptist de La Salle, and the Animosaic.

These include heterogeneous sectioning at all levels, the Cornerstone Project, and Problem-Based Learning, all aimed at fulfilling the school’s vision and mission of providing students with excellent, holistic, and inclusive education.

To enhance facilities for students, parents, and staff, several infrastructure projects were completed, including a covered volleyball court outside the gym, new gymnasium restrooms, a robotics laboratory, and a school chapel.

With the coronavirus pandemic affecting the regular operations of schools, La Salle Academy developed the Sound, Authentic, Flexible Education (SAFE) program.

The program aims "to continue its vision and mission of giving quality Lasallian education through Sound activities that went through careful planning, Authentic delivery, instruction and assessments, and Flexible modalities offered to cater to the present situation."

The new leadership envisioned a six-point agenda: Inclusive and Innovative Curriculum, Holistic Personnel, Global-ready Learners, Upgraded and Modern Facilities, Strong Partnership & Linkages, a Relevant Extension Program, and Sustainable Fiscal Management.

Taking into consideration the evaluation from students, parents, faculty, and administrators, the academic team coined the term SAFER to stand for Sound, Authentic, Flexible Education Refined for its program this school year.