The university offers preschool, elementary, secondary (junior & senior high), undergraduate, and graduate programs.

It has seven colleges namely: Business and Accountancy, Engineering and Technology, Arts and Sciences, Education, Nursing, Law, and Medicine.

La Salle College-Bacolod opened with 175 male students from Prep to Grade 5, under seven faculty members.

The school building was unimpressive, built amidst sprawling muddy grounds and bordered by cane fields of adjoining lands.

The USLS Health Sciences Campus, located at Lacson St., is an additional facility for students under its Nursing and Medicine program.

On October 7, 2024, the USLS unveiled its expansion in Pavia, Iloilo through a partnership with Property Company of Friends, Inc.