The school was opened September 6, 1960, and was named in honor of Jean-Baptiste de La Salle, a French priest, and educational reformer.

[8] Students are able to take handwritten notes in Microsoft OneNote, submit assignments and check grades online, as well as communicate with their teachers directly via email.

[9] In preparation for its laptop program, the school installed a Cisco wireless network, Moodle course management system, PowerSchool student information system, and implemented its own private cloud infrastructure with Hyper-V.[8] Students in the Honors or Advanced College Preparatory programs are required to take at least two consecutive courses in the same foreign language during their freshman and sophomore years.

At least half of those hours must directly involve working for the homeless, poor, crippled, sick, elderly or others struggling in their lives.

[7] La Salle High School hosts an annual Truck Full of Love canned food drive.

The department's production of "The 25th Annual Putnam County Spelling Bee" was also selected to perform a full-length show at the conference in 2022.

La Salle's Wind Ensemble has also received a Superior rating in classes C, B, and A consecutively at adjudicated OMEA events.