The first graduating class of 1953 consisted of 159 students,[2] including several prominent Clevelanders, most notably talk show host Phil Donahue.

[3] St. Edward High School offers a rigorous college-preparatory curriculum and several specialized programs, including pre-engineering, business and entrepreneurship, and film.

[5] Construction on the school's current facility began in 1949 on a site that once served as a resting and feeding stop for cattle trains passing through from western states to eastern markets on what is now known as the Norfolk Southern roadbed.

A year later, new freshmen were taught in makeshift classrooms in the basement of St. James Grade School, located roughly 1.5 miles away at the corner of Detroit Road and Granger avenues.

In 2000, the school began a capital campaign to upgrade and transform the physical plant, including a new gym, weight room and indoor track.

[6] The facility was named after the parents of Gregg Lowe, the former senior vice president of High-Performance Analog Business Units at Texas Instruments and a 1980 graduate of the high school.

[13] The chapel contains a bronze sculpture of Jesus on the cross created by St. Edward alumnus and sculptor James McKenna who also makes head busts for the Pro Football Hall of Fame.

In September 2016, St. Edward launched its Courage to Act capital campaign revolving around three pillars: Affordability, Innovation, and Hospitality.

This sum was used to increase the school's endowment; expand the Joseph & Helen Lowe Pre-Engineering and Technology Center, renaming it the Joseph & Helen Lowe Institute for Innovation; and construct the Marilyn and David Palisin '64 Commons, a new entrance and dining hall which opened prior to the start of the 2020-2021 school year.

Whidden retired in 2005, having coached the team to ten state titles during his tenure and was named to the St. Edward's Athletic Hall of Fame in 2009.