The original curriculum stressed classical studies, language skills, doctrinal religion and strict discipline.

In the years following World War I, Youngstown, Ohio witnessed an unmatched period of growth and prosperity.

The Ursulines began a fundraising drive almost immediately upon moving into the Andrews Estate to build a new school that could accommodate 400 students.

Groundbreaking was held in 1924, and in April 1925 the student body moved into a three-story brick building on Bryson Street.

Currently, Ursuline fields 17 varsity teams for both boys and girls and celebrates a long-standing athletic rivalry with Cardinal Mooney High School, another Diocese of Youngstown high school located on Youngstown's south side.