The school also had soccer, volleyball, tennis, cross country, swimming, bowling, track and field, and softball teams.

Regina High School was noted in the greater Cleveland Catholic community for its Clown Ministry, a group that dons face paints and performs sign language that is often religious in nature.

The club performs the Stations of the Cross (set to contemporary music) every year and raises money for charities.

Visiting nursing homes, serving meals at hunger centers, raising money for various organizations in need, and many other activities show only a portion of how loving and giving these girls truly are.

Regina's newsmagazine, the Regent, has won awards from the Northeast Ohio Scholastic Press Association for its writing and layout.

The summer student-directed plays include Alice in Wonderland, The Canterbury Tales, Snow White, and Rumpelstiltskin.

A letter from the Board of Directors stated that economic downturn and drops in enrollment were the reason for the closing.