La Sierpe is a municipality and town in the Sancti Spíritus Province of Cuba.

It is located in the south-eastern part of the province, 30 kilometres (19 mi) from Sancti Spiritus, the provincial capital.

It borders the Gulf of Ana Maria of the Caribbean Sea to the south and the province of Ciego de Ávila to the east.

In 2022, the municipality of La Sierpe had a population of 16,937.

Media related to La Sierpe, Cuba at Wikimedia Commons