It occurs and is detectable with a manual examination at about 6 weeks' gestation.
[1] Ladin's sign is often present during the woman's first pelvic exam when pregnancy is suspected.
[2] Cervical length is also significant in pregnancy and shorter or shortening length can increase chances of preterm labour and delivery as this shortening happens naturally at the beginning of labour.
[3] The cervix softens from conception and combined with other signs of early pregnancy, detecting Ladin's sign can assist clinicians in verifying a diagnosis of pregnancy.
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