Lagoa Santa is located on the border with the state of Mato Grosso do Sul, divided by the Aporé River, a tributary of the Paraná.

Connections with the state capital are made by BR-060 / Abadia de Goiás / Guapó / Indiara / Acreúna / Rio Verde / GO-174 / GO-422 / Caçu / GO-206 / Itarumã / GO-178 / Itajá / GO-302.

It has boundaries on the north, east, and west with Itajá, and on the south with the state of Mato Grosso do Sul.

In the tropical forest along the river there is a natural lake, Lagoa Santa, with water temperatures of around 31 °C.

The economy is based on services, government jobs, modest agriculture and cattle raising, and income generated from tourism.