Laguna de Guayatayoc is a body of salty water in Argentina, located in the south of the Cochinoca Department, in the province of Jujuy.

Its surface area is highly variable, depending on the season and longer cycles of drought and humidity.

In the puna ecoregion, summer (December–March) is the rainy season; hence the lake is largest in March and April.

It covers an area of approximately 240 square kilometres (93 sq mi) and is about 6 metres (20 ft) deep.

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