Lake Nipisso is in the unorganized territory of Rivière-Nipissis in the Sept-Rivières Regional County Municipality, Côte-Nord.

[1] It is about 75 kilometres (47 mi) north of northeast of Sept-Îles and is in the Duplessis (Côte-Nord) tourist region.

[2] The lake is a widening of the Nipisso River, which flows into its north end from Lac Premio-Réal and Lac de Mouches in the northeast, and continues from its south end in a southeast direction to the Nipissis River, of which it is a tributary.

[8] The region is near the southern border of the Canadian Shield, and is a rolling to rugged upland, with mountains reaching 2,100 feet (640 m).

[15] A 1997 study of a mineral property about 2/3 of the way up the east shore found most of the units present in the Nipisso-Manitou geological complex, including felsic gneisses, abundant gabbro and minor granitoid intrusives.