Written and produced by long-time collaborator Teddy, along with Bekuh Boom and 24, "Lalisa" was described as a hip hop track containing influences from Thai culture.

The song reached number one in Malaysia and the top ten in Hungary, India, and Singapore, and figured within the record charts of 18 countries.

An accompanying music video was directed by Seo Hyun-seung and simultaneously uploaded to Blackpink's YouTube channel with the single's release.

In an article published by The Korea Herald on April 19, a representative from YG Entertainment revealed that Lisa would debut as the third soloist from her group with schedules to be officially announced through a notice later in the year.

[9] "Lalisa" is characterized as a dynamic hip hop and EDM track that infuses Thai elements in the song's dance break.

[2] The track's production utilizes "provocative" brass riffs and dynamic rhythms that are reminiscent of sounds of sirens, and incorporates the repetition of 'Lalisa' in the lyrics.

[10] Nolan Feeney from Billboard noted that the "title track expands on the maximalist, globe-trotting sound of Blackpink bangers like 'How You Like That' with rapid-fire flows and nods to her Thai heritage".

Allison S. Park, writing for The Harvard Crimson, highlighted Lisa's "formidable" rapping skills but criticized the "absence of a cohesive lyrical narrative.

[13] Park Soo-jin of IZM echoed similar sentiments, stating that while the song showcased Lisa's Thai identity and musical prowess, it fell short of being impressive.

[20] In South Korea, the song debuted at number 90 on the Gaon Digital Chart on the week dated September 5–11, with less than two days of tracking.

[43] Following the release of her single album on September 10, 2021, Lisa debuted the title track the same day on The Tonight Show Starring Jimmy Fallon.

[47][48] The song was included on the setlist as part of Lisa's solo stage during Blackpink's Born Pink World Tour starting in October 2022.

[49] On January 26, 2024, Lisa performed a medley of "Lalisa" and "Money" at the Le Gala des Pièces Jaunes charity event organized by the First Lady of France, Brigitte Macron, in Paris.