It travels in a south-south-westwardly direction past the town of Lanigan and into the northern end of Last Mountain Lake.

At the southern end of Lanigan Creek, at the point it empties into Last Mountain Lake, there's Last Mountain Lake Bird Sanctuary, which was North America's first migratory bird sanctuary.

[6] Lanigan-Manitou Sub-basin is the name given to Lanigan Creek's drainage basin.

The combined area of all four sub-basins and the Moose Jaw River Watershed is 23,443 km2.

[9] Along the course of Lanigan Creek is Boulder Lake,[10] which is located just east of Venn about 20 kilometres (12 mi) south-east of Watrous.