She made eight voyages for the British East India Company (EIC), and then briefly became a West Indiaman.

Homeward bound, she crossed the Second Bar on 7 January 1781, reached St Helena on 25 June, and arrived at The Downs on 19 October.

[3] EIC voyage #2 (1783–1784): Captain Wakefield sailed from Portsmouth on 11 March 1783, bound for Madras and China, and arrived back at The Downs on 12 July 1784.

Homeward bound, she crossed the Second Bar on 15 October, reached St Helena on 16 February 1786, and arrived at the Downs on 28 April.

[3] EIC voyage #4 (1787–1788): Captain Richard A. Farrington sailed from The Downs on 17 January 1787, bound for Madras and China.

Charlotte had grounded on the reef and Wood had moved some of her stores to shore to lighten her to enable him to get her off when a Malay proa had arrived.

Homeward bound, she crossed the Second Bar on 29 November, reached St Helena on 24 February 1790, and arrived at the Downs on 25 April.

Homeward bound, she crossed the Second Bar on 12 November, reached St Helena on 28 February 1793, and arrived at the Downs on 2 May.

[3] The EIC inspected the East Indiamen as they arrived and on 15 October fined Farrington and eight other captains £100 each for having not stowed their cargoes in conformance with the Company's orders.

The British government chartered Lascelles, together with numerous other Indiamen and country ships, to serve as a transport in a planned attack on Manila.

When the British Government cancelled the invasion following a peace treaty with Spain, it released the vessels it had engaged.

[2] On 8 October 1799 the "Lascelles East India store ship" sailed from Plymouth for The Downs under escort by HMS Childers.