Laslo Djere was born on 2 June 1995 to mother Hajnalka and father Csaba (or Čaba) Đere in Senta, at the time part of the Federal Republic of Yugoslavia.

His last tournament of 2014 season was in December, at Senegal F2 Futures in Dakar, where he had success, and won title, winning against Aldin Šetkić in final.

Djere started 2015 season successfully, playing in the semifinal of Morocco Tennis Tour – Casablanca, where Javier Martí stopped him to reach his first Challenger final.

In late January, he won Egypt F3 Futures in Cairo, defeating Kamil Majchrzak in straight-sets.

At Dubai Tennis Championships, he made his first attempt to play at some ATP 500 Series event, but failed in the second round of qualification, losing from Lucas Pouille.

At French Open, he played in qualification, trying to reach his first main-draw at any grand-slams, but lost in the first round from Nikoloz Basilashvili.

By the end of the year, he played quarterfinal at Morocco Tennis Tour – Casablanca II, and semifinal at Sparkassen ATP Challenger in Ortisei.

In January, Djere played at Australian Open qualification, but lost in second round from Ivan Dodig, missing his chance to debut in main-draw there.

In April 2017, Djere recorded his first ATP main draw win at the Grand Prix Hassan II over Martin Kližan, before losing to second seed Albert Ramos Viñolas.

Following the successes on the ATP level, he played in challengers during the summer, winning one (2017 Internazionali di Perugia) and reaching three other finals, which enabled him to break the top 100 for the first time on 24 July 2017 at No.

In September, Djere made his Davis Cup debut for Serbia in their 2017 semifinal clash against France, losing in straight sets to Jo-Wilfried Tsonga.

[14] In November, he played his first ATP Masters 1000 qualification, but wasn't good enough to beat Filip Krajinović in the second round, and qualify to main-draw.

[17] He recorded his first Grand Slam main draw win by defeating Leonardo Mayer at the US Open, before losing to Richard Gasquet in the second round when he failed to convert all 12 of his break point opportunities.

[18][19] He next played a home tie against India in the Davis Cup World Group play-offs, where he defeated Ramkumar Ramanathan in the opener for his first career win in a Davis Cup match and Serbia eventually won the tie 4–0.

[14] On 24 September 2018, after making semifinal at Sibiu Open, Djere reached a then-career high of world No.

In February, Djere won his first ATP title at the Rio Open, defeating Dominic Thiem in the process for the first top 10 win of his career and reached a then-career high ranking of No.

During the trophy presentation in Rio, Djere dedicated the title to his late parents in an emotional speech.

[23] He next played in Indian Wells, where he was seeded for the first time in his career in an ATP event (despite being a wildcard entrant), receiving a first round bye and then defeating Guido Andreozzi for his first Masters 1000 win, before being defeated by countryman Miomir Kecmanović in the third round, his best career showing at a Masters 1000 level.

[25] He next reached the third round of Madrid Masters, where he defeated Juan Martín del Potro for his second top 10 win, before losing to Marin Čilić.

[26][27] Winning only one match at the Rome Masters (lost in round two to Basilashvili), coupled with a few withdrawals proved to be enough for Djere to be seeded at a Grand Slam for the first time in his career.

[28] In October, Djere won the inaugural Forte Village Sardegna Open by beating home favorite Marco Cecchinato in straight sets in the finals.

[29] In April, he reached the final of Sardegna Open where he lost in three tight sets against home favorite Lorenzo Sonego.

[30] Djere reached the third round of a Grand Slam for a second time at the 2021 French Open where he was defeated by sixth seed Alexander Zverev.

[32] Seeded eighth at the Argentina Open, Djere lost in the first round to compatriot, Miomir Kecmanović, in three sets.

[37] At the 2022 Winston-Salem Open he reached his fourth ATP tour final defeating David Goffin,[38] 16th seed João Sousa, qualifier Jason Kubler, Richard Gasquet and qualifier Marc-Andrea Huesler after needing 9 match points to win.

[44] At the Australian Open, he got his first win at this Major event by beating qualifier Zizou Bergs in the first round.

[62] In August, Djere reached the semi-finals in Kitzbühel, where he was defeated in three sets after exactly three and a half hours of play by Dominic Thiem, despite having 5 match points.

In the first round he beat Brandon Nakashima, while in the second, he defeated Frenchman Hugo Gaston, both times in straight sets.

1 for the first time, won against Kwon Soon-woo from South Korea and gave the all important second point to his Serbian Davis Cup team.

[68] In October, Djere reached semifinals of Stockholm Open, by beating Leo Borg in the first, J. J. Wolf in the second round and outlasting Tomáš Macháč in the quarterfinals.