[9] Medjedovic reached the final at the 2022 Platzmann-Sauerland Open as a qualifier, eliminating both fourth-seeded Marco Cecchinato and top seed Nicolás Jarry en route.

[10] In February, Medjedovic recorded his first ATP Tour win, when he made his debut in the Davis Cup by beating Viktor Durasovic in the tie against Norway which Serbia won 4:0.

[11] In March, Medjedovic won his second Challenger title at the Kiskút Open after defeating Nino Serdarušić in the final in straight sets.

214, he moved close to 50 positions up in the rankings to a new career high into the top 170 following his third Challenger title at the 2023 Upper Austria Open where he defeated three Austrians including former world No.

[13] In May, Medjedovic made his Grand Slam debut at the French Open where he qualified to the main draw with victories over Ivan Gakhov, Juan Manuel Cerúndolo,[14] and Jesper de Jong,[15] He lost in the first round to Marcos Giron.

He beat Zhang Zhizhen in the first round, Dominic Thiem in the second and fourth seed Yannick Hanfmann in the quarterfinals in straight sets.

[28] He made debut at a Masters 1000 at the 2024 Mutua Madrid Open after qualifying for the main draw and recorded his first win at this level over Aleksandar Kovacevic.

[33] At the 2024 Belgrade Open where he received a wildcard, he reached his maiden final with wins over third seed Francisco Cerúndolo[34] and compatriot Laslo Djere.