[3] The list of nominees for the 1st Annual Latin Grammy Awards, slated for September 13, 2000 in Los Angeles, was unveiled on Friday, July 7, 2000, in a Miami ceremony hosted by Michael Greene, President of the National Academy of Recording Arts & Sciences.

Christina Aguilera, received a nod on the Latin side of the musical divide for the Spanish-language remake of "Genie in a Bottle" titled "Genio Atrapado".

[4] The list of hosts for the first-ever Latin Grammy Awards, included Gloria Estefan, Antonio Banderas, Jimmy Smits, Andy García and Jennifer Lopez,[5] who also was announced to perform her hit single "No Me Ames" with Marc Anthony, but Anthony (with six nominations that night) did not attend the show citing complications with his (then) wife's pregnancy.

[2] The telecast kicked off with a tribute to the late Tito Puente featuring Ricky Martin, Celia Cruz, and Gloria Estefan.

Performances throughout the show included Santana & Maná, 'N Sync & Son By Four, Christina Aguilera, Shakira, Miami Sound Machine and Alejandro Fernández.

[7] The nominations were announced on July 7, 2000[8] and the winners were revealed on September 13, 2000, including Maná, Luis Miguel and Santana each grabbing three trophies at the event.

Santana featuring Maná – "Corazón Espinado" Luis Miguel – Amarte Es Un Placer Marc Anthony, Robert Blades, Angie Chirino and Cory Rooney – "Dímelo" (Marc Anthony) Ibrahim Ferrer Shakira – "Ojos Así" Luis Miguel – "Tu Mirada" Maná – "Se Me Olvidó Otra Vez" Santana – "El Farol" Luis Miguel – Amarte Es Un Placer Shakira – "Octavo Día" Fito Páez – "Al Lado del Camino" Santana featuring Maná – "Corazón Espinado" Fito Páez – "Al Lado del Camino" Café Tacuba – Revés/Yo Soy Celia Cruz – Celia Cruz and Friends: A Night of Salsa Juan Luis Guerra 440 – Ni Es Lo Mismo Ni Es Igual Tito Puente – Mambo Birdland Juan Luis Guerra – "El Niágara en Bicicleta" Alejandro Fernández – Mi Verdad Banda el Recodo – Lo Mejor De Mi Vida Los Temerarios – En La Madrugada se Fue Los Palominos – Por Eso Te Amo Los Tigres del Norte – Herencia de Familia Kike Santander – "Mi Verdad" (Alejandro Fernández) Mercedes Sosa – Misa Criolla Lito Vitale and Juan Carlos Baglietto – Postales del Alma Camarón and Tomatito – Paris 87 Michel Camilo and Tomatito – Spain / Paquito D'Rivera – Tropicana Nights (tie) Milton Nascimento – Crooner Os Paralamas do Sucesso – Acústico MTV Zeca Pagodinho – Zeca Pagodinho ao Vivo Caetano Veloso – Livro Sérgio Reis – Sérgio Reis e Convidados Paulo Moura & Os Batutas – Pixinguinha Djavan – "Acelerou" Miliki – A Mis Niños de 30 Años Plácido Domingo – La Dolores Carlos Álvarez, Mike Couzzi, Bolívar Gómez, Miguel Hernández, Luis Mansilla, Carlos Ordehl, Eric Ramos, July Ruiz, and Eric Schilling – Ni Es Lo Mismo Ni Es Igual (Juan Luis Guerra) Emilio Estefan Jr. Gloria Estefan – "No Me Dejes de Querer"