[11][12] For the 2022 season Van Hoepen moved to the Formula Regional European Championship with ART Grand Prix, partnering Gabriele Minì and Mari Boya.

[23][24] Van Hoepen began the year by fighting for victory at the Bahrain sprint race, losing out to Arvid Lindblad but overcoming teammate Nikola Tsolov to finish second on debut.

[29][30][31] Further points followed on Saturday at Silverstone before Van Hoepen qualified on pole at the Hungaroring, benefiting from a late red flag which came out before many of the other contenders could set a lap time.

[32] Despite losing the lead to Tsolov on lap 1, Van Hoepen crossed the line in second; however he would be disqualified due to his car being underweight, which was later revealed to have been caused by a water radiator leak.

[33][34][35] Van Hoepen scored more points in the sprint at Spa and the feature in Monza, where he had risen from 29th on the grid owing to an accident in qualifying caused by Kacper Sztuka to 13th and eighth in the two races.