Law of definite proportions

that iron like many other metals is subject to the law of nature which presides at every true combination, that is to say, that it unites with two constant proportions of oxygen.

In this respect it does not differ from tin, mercury, and lead, and, in a word, almost every known combustible.At the end of the 18th century, when the concept of a chemical compound had not yet been fully developed, the law was novel.

In fact, when first proposed, it was a controversial statement and was opposed by other chemists, most notably Proust's fellow Frenchman Claude Louis Berthollet, who argued that the elements could combine in any proportion.

This variation is used in radiometric dating since astronomical, atmospheric, oceanic, crustal and deep Earth processes may concentrate some environmental isotopes preferentially.

Polymers are generally not considered "pure chemical compounds" except when their molecular weight is uniform (mono-disperse) and their stoichiometry is constant.