The club currently plays in the Liga de Expansión MX, the second level division of Mexican football.

During their first years in the top flight they had several skilled Brazilian players, reason for which noted sports broadcaster Ángel Fernandez started to call them "Leones Negros" (the Black Lions), a nickname that stuck and remains part of the folklore of Mexican football.

After the disappearance of the team by the Federación Mexicana de Futbol, the franchise maintained the third division reserve squad, that become the main team, the club obtained a title in the verano 1997 tournament, gaining promotion to the Primera División "A" where they stayed until the franchise was sold and moved to Orizaba in 2002.

[4] For some time businessmen, among them Jorge Vergara, tried to return the team of Club Universidad de Guadalajara to the top divisions of football in Mexico, this was achieved through the purchase of the franchise of Primera División A's CD Tapatio for $800,000 USD from Guadalajara of which CD Tapatio was a subsidiary.

After a hard Clausura 2014 tournament, Leones Negros ended in 4th place, but lost in the quarterfinals against Oaxaca.

[5] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.