He wrote in the Russian and Ukrainian languages and published more than 60 books of poems, prose and translations.
In his youth he was interested in futurist poets, especially Vladimir Mayakovsky, (many years later, he wrote about him literary studies).
Since 1948 until 2002 Vysheslavskyi was the editor of the magazine Raduga (means: rainbow), (renamed in 1963 from "Soviet Ukraine").
One of the main themes in the Vysheslavskyi's poetry is a flight into space, as a human contact with the Universe.
Vysheslavsky had active creative life and communication with prominent contemporaries: priest Alexander Men, poets David Burliuk, Boris Pasternak, Mykola Zerov, Pavlo Tychyna, Ivan Drach and other.