Its location is the cell membrane, and it has extracellular, trans-membrane and intracellular sections (protein regions).

The extracellular part has 5 functional domains:[12] i) membrane distal 1st cytokine receptor homology (CRH1), ii) Immunoglobulin like (Ig), iii) 2nd cytokine receptor homology (CRH2) and iv) two membrane proximal fibronectine type-III (FNIII) domains.

[12] Ig domain interacts with Leptin and is essential for conformational change in the receptor upon ligand binding.

[16] Variations in the leptin receptor have been associated with obesity[17][18] and with increased susceptibility to Entamoeba histolytica infections.

[23] This article incorporates text from the United States National Library of Medicine, which is in the public domain.