Levomethorphan (LVM) (INN, BAN) is an opioid analgesic of the morphinan family that has never been marketed.

[5] As a prodrug of levorphanol, levomethorphan functions as a potent agonist of all three of the opioid receptors, μ, κ (κ1 and κ3 but notably not κ2), and δ, as an NMDA receptor antagonist, and as a serotonin-norepinephrine reuptake inhibitor.

[5] Via activation of the κ-opioid receptor, levomethorphan can produce dysphoria and psychotomimetic effects such as dissociation and hallucinations.

[6] Levomethorphan is listed under the Single Convention on Narcotic Drugs 1961 and is regulated like morphine in most countries.

The salts in use are the tartrate (free base conversion ratio 0.644) and hydrobromide (0.958).