The district includes 122 contributing buildings and 6 contributing sites encompassing most of the 17th-century town of Lewes, together with part of Pilot Town.

The district is primarily residential with resources ranging from small working-class houses to large and ornate houses from the Victorian period in a variety of popular styles including Queen Anne and Second Empire.

Also included in the district is the Market Street commercial area, including three frame store buildings and the elaborate Smith Block.

Other notable buildings include St. Peter's Episcopal Church, the Ellis Marine Complex, Cannonball House, Governor Ebe W. Tunnell House, Walsh Building, Zwaanendael Museum (1932), Cornelius Burton House, Lewes Historical Society enclave, and the De Wolf Houses.

This article about a property in Delaware on the National Register of Historic Places is a stub.