Lewiston competes in Maine's Class A division for sports, the highest class in the state (except for basketball, which competes in AA), as governed by the Maine Principals' Association.

Lewiston is also a member of the Kennebec Valley Athletic Conference.

Lewiston's Blue Devils boys soccer team won the state championships in 2015 and 2017[2][3] under coach Mike McGraw.

The team won again in 2023 under coach Dan Gish, shortly after the mass shooting that devastated the community.

[4] The story of Somali immigrants to Maine and how their passion for soccer led Lewiston to their first state championship title in 2015 is told in the 2018 book One Goal by Amy Bass.