Although not considered to be one of the foremost of the Poets of the Nobility, his work provides a portrait of the gentry society of north-west Wales at the start of the Tudor period.
On the basis of his name and a reference to him in a later 16th-century manuscript in the hand of the antiquary Thomas Wiliems, it can confidently be accepted that he was a native of the parish of Aberdaron in Llŷn.
Lewys Daron sang to patrons in Arfon, Meirionnydd, Eifionydd and Llŷn, an area corresponding to the modern county of Gwynedd in north-west Wales.
His patrons included the Stradlings and the gentry families of Penrhyn, Bodfel, Bodeon, Glynllifon, Carreg, Cochwillan (near Bethesda), Plas Iolyn (near Ysbyty Ifan) and others.
He also wrote a praise poem to Pîrs Conwy, Archdeacon of Llanelwy (St Asaph).