Lexitropsin

Lexitropsins are members of a family of semi-synthetic DNA-binding ligands.

[1] They are structural analogs of the natural antibiotics netropsin and distamycin.

Antibiotics of this group can bind in the minor groove of DNA with different sequence-selectivity.

[2][3] Lexitropsins form a complexes with DNA with stoichiometry 1:1 and 2:1.

Based on the 2:1 complexes were obtained ligands with high sequence-selectivity.