It flows west-northwest through a deep, broad valley for several tenths of a mile, entering Washington Township, Lycoming County.

It then turns south for more than a mile, reentering White Deer Township, Union County, receiving an unnamed tributary from the left, and passing by Little Mountain.

The stream then crosses Interstate 80 and continues flowing south for a few tenths of a mile before turning southeast and reaching its confluence with White Deer Creek.

[3] The White Deer Valley Railroad, which was incorporated on December 11, 1900, passed in the vicinity of Lick Run.

[5] By the early 1900s, the remains of an old log cabin had been discovered near the headwaters of Lick Run, on the road to the "Lost Valley".