As a member of the 2000s resurgence of the poster-art scene he has designed posters for a wide variety of musical acts, including Devo, Slayer, Pavement, Queens of the Stone Age, Faith No More, The White Stripes, The Black Keys, Morrissey and many others.

[citation needed] Tuffy's artistic style is greatly influenced by Postminimalism, as well as advertising artwork of the 20th century.

Although he works in a variety of styles, it primarily incorporates limited color palettes, simple typography and the use of negative space.

[citation needed] Tuffy's artwork has been featured in various books including The Art Of Modern Rock, Panda Meat Vol.

[citation needed] He is featured in 2012 documentary Just Like Being There and his posters were used as set dressing for the Lindsay Lohan movie Just My Luck and the television shows Looking and Sense8.