2704016797ENSG00000213658ENSMUSG00000030742O43561O54957NM_001014987NM_001014988NM_001014989NM_014387NM_010689NP_001014987NP_001014988NP_001014989NP_055202NP_034819The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene.

[6] The LAT protein encoded by the gene of the same name, plays a key role in the diversification of T cell signaling pathways following activation of the T-cell antigen receptor (TCR) signal transduction pathway, which is first catalyzed by TCR binding to MHC class II.

[8] Prior to phosphorylation of LAT, the TCR signal transduction pathway is initiated by a TCR interacting with peptide bound MHC, and immediately leads to the activation of LCK and Fyn, which are members of the Src family of kinases.

[8] Activated LCK subsequently phosphorylates the immunoreceptor tyrosine-based activation motifs (ITAMs) of the T-cell surface glycoprotein CD3 zeta chain, which is a protein associated with the TCR complex, in two specific locations.

[5][13] The Linker for Activation of T cells has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.