1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4WAF, 5AUL529518708ENSG00000145675ENSMUSG00000041417P27986P26450NM_001242466NM_181504NM_181523NM_181524NM_001024955NM_001077495NP_001229395NP_852556NP_852664NP_852665NP_001020126NP_001070963Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.

It used to be thought that alternative splicing of this gene resulted in three transcript variants encoding different isoforms.

[6] In fact, it has since been shown that the 55 and 50kD subunits have their own promotors within the gene locus Pik3r1.

[8] Suppression specifically of the 85kD subunit in early murine embryoid body development results in a transient cell-cell adhesion deficiency, mediated by transient downregulation of the adhesion molecule integrin-beta1 (ITGB1).

[7] Mutations in PIK3R1 are implicated in cases of breast cancer.