1HSQ, 2HSP, 4EY0, 4FBN533518803ENSG00000124181ENSMUSG00000016933P19174Q62077NM_002660NM_182811NM_021280NP_002651NP_877963NP_067255Phospholipase C, gamma 1, also known as PLCG1 and PLCgamma1, is a protein that in humans involved in cell growth, migration, apoptosis, and proliferation.

[7] PLCγ1 roles are also involved in neuronal actin growth, calcium signaling, and brain development.

In neuronal cells, PLCγ1 is highly involved in actin cytoskeleton organization and synaptic plasticity.

This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators.

For example, in T cells, Lck and Fyn (Src family kinases) phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the T-cell antigen receptor (TCR).

In vitro studies have shown signs of PLCγ1 having many cell-motility functions, however in vivo have not been able to show a physiological role for PLCγ1.

[18] While PLCγ1 is well documented and easily found in the body, clear connections and roles for PLCγ1 have been difficult to find in in vivo studies.

[20][21] Tissue samples from cancer patients the PLCγ1 levels are not elevated, however, regulatory factors for this proteins are lowered and that amplification of PLCγ1 is extremely high.

Studies also showed that adding new regulatory to cells in vitro helped reduce previously amplified PLCγ1.