He accidentally turns himself into a human and he and Johnny, who is now a dragon-like monster, go to the Amazon Rainforest to find a cure for this mess on the orders of Abraham Van Helsing, Drac's great-grandfather-in-law.
After thinking that she would be better off without a human partner he leaves the hotel, but Drac reconsiders and chases the plane Johnny has boarded, bringing him back.
Johnny agrees to take Mavis to California ostensibly to consider moving back home to be near his parents, while Drac tries to prompt Dennis' vampire abilities.
Due to his human limitations, Johnny is a background character in the final encounter, but the threat to his life helps Dennis manifest his vampire traits.
Despite this, he is instrumental in defeating the Kraken, using his portable DJ booth to play up-beat music to calm the monster down, ultimately succeeding with the Spanish song Macarena.
In the second movie, he aids Dracula in his quest to turn Dennis to awaken his vampire lineage and joins the rest of the gang in repelling the attack by Bela and his minions.
After Frank is restored to normal, Eunice butchers his hair back to its previous length In the prequel TV series, it is revealed that she is the mother of Hank N Stein.
In the final fight against Bela's goons, he is quickly overrun, but summons his enormous pack of children, who make short work of several of the attackers.
In the fourth movie, Wayne renames himself as Walter, after unknowingly drinking water from a fountain that was accidentally contaminated by Van Helsing's Monsterfication Ray, allowing himself to escape the stress from unable to control his chaotic children and leaves Wanda on her own.
Wanda (voiced by Molly Shannon in the films and Diane Salema in the TV series) is a female werewolf, the wife of Wayne, and the mother of Winnie and the rest of the wolf pups.
Griffin (voiced by David Spade in the films and Daniel Bonjour in Hotel Transylvania: Scary-Tale Adventures) is an invisible man and the only thing that can be seen are his brown glasses.
When he unknowingly drinks water from a fountain that was contaminated by Van Helsing's Monsterfication Ray in the fourth movie, Griffin becomes displeased when seeing his human appearance.
Murray (voiced by CeeLo Green in the first film, Keegan-Michael Key in the last three films and Hotel Transylvania 3: Monsters Overboard and Kyle Chapple in Hotel Transylvania: Scary-Tale Adventures) is an obese mummy from Egypt who has the power to summon sandstorms or just sand to cast ancient Egyptian curses.
In Hotel Transylvania 3: Summer Vacation, Winnie helps Dennis sneak Tinkles onto The Legacy, but otherwise has no prominent role.
In the prequel TV series, Quasimodo is depicted with yellow hair and puts up with the criticism of his cooking from Mavis, her friends, and Aunt Lydia.
The zombie versions of Johann Sebastian Bach, Ludwig van Beethoven, and Wolfgang Amadeus Mozart are shown as some of the entertainment at Hotel Transylvania.
The Hotel Transylvania guests includes: The Elderly Gremlin is a character who has a running gag through the series where she eats something in one bite and says "I didn't do that".
In Hotel Transylvania: The Series, which is set four years before the original film, Martha was referenced in the season finale "Fangcenera" when Dracula had presented Mavis her mother's blood-red black formal gown for her one hundred-and-fifteenth birthday.
Dennis (voiced by Sunny Sandler as a baby and Asher Blinkoff as a child) is Johnny and Mavis' human/vampire hybrid son, born on Friday the 13th.
Dennis has only a supporting role, but Tinkles forms part of the assault on the Kraken and Van Helsing's musical DJ booth.
Ironically, Vlad defends Dennis to Drac, supporting the theory that he is a "late fanger" and will show his vampire traits when put under stress.
In Hotel Transylvania 2, Johnny and Mavis hire Brandon to perform as Kakie for Dennis' birthday party near the film's climax.
As Dracula turns Kakie back to normal, Brandon is heard inside the costume proclaiming that none of the parents better review the situation on Yelp.
During Dracula's heated argument between Mavis and Jonathan, they get fed up with the Phantom of the Opera playing his music during this time and shout at him to shut up.
Pandragora (voiced by Paul Brittain) is a monster with tentacles for hair who lives in Mike and Linda's neighborhood in Santa Cruz.
Ericka is part of Abraham's plan to kill Drac and all monsters, by taking them on The Legacy to Atlantis where they will all be destroyed by an "Instrument of Destruction", found only in the lost city's ruins.
Despite Van Helsing's plan, Ericka makes several attempts to kill Drac, but starts to see him as a family man rather than a monster.
Professor Abraham Van Helsing (voiced by Jim Gaffigan) is a former monster hunter and archenemy of Count Dracula, Frankenstein, Wayne, Griffin and Murray.
In 1897, Abraham Van Helsing tracked a disguised Drac, Frankenstein, Griffin, Murray and Wayne to a train, but was unsuccessful in killing them.
Drac rescues him, making him realize monsters are not as he previously thought, and he ceases attempting to kill them including offering refunds to the guests.