[6] Upon entering Pickens County, the highway travels 4.3 mi (6.9 km) north by northeast before intersecting at SC 133.

[6] Traveling east by northeast on Walhalla Highway, SC 183 goes 5.8 mi (9.3 km) before reaching downtown Pickens, the county seat.

[6] It then moves eastward 8.32 mi (13.39 km) where it intersects US 25 in Greenville County, crossing over the Saluda River in the process.

[7] SC 183 travels an additional 1.79 mi (2.88 km) southeast, becoming Pete Hollis Boulevard, and intersecting Stone Avenue and Rutherford Street.

[7] It has a second intersection with US 123 at North Academy Street in downtown Greenville a further 0.41 mi (0.66 km) southeast.