Crossing SC 28 Bus., the road widens to an undivided four-lane highway, continuing until reaching River Street (US 76/US 178); where US 29 makes another right turn and then soon left again.

Church Street eventually ends onto Wade Hampton Boulevard, which is a divided six-lane highway from Greenville to Greer.

[6] After passing through Cowpens, the road widens again to an undivided four-lane highway for 2.7 miles (4.3 km) before entering into Gaffney.

Continuing as a two-lane road through both Gaffney and Blacksburg, it crosses one last time with I-85 (exit 106), before entering North Carolina.

[6] From its inception until 1959, US 29 was the main thoroughfare in Upstate South Carolina and connecting regionally with Atlanta and Charlotte.

Established in 1927 as an original U.S. Highway, it generally traversed the same today as it then when created; from Georgia to North Carolina, via Anderson, Greenville, Greer, Spartanburg, Gaffney, and Blacksburg.

[7] By 1955, US 29 was rerouted onto a new super-two highway north of Spartanburg, Cowpens, Gaffney, and Blacksburg; the old route became US 29 Alternate (US 29 Alt.).

[8] In 1957 or 1958, US 29 was rerouted onto a new super-two highway, bypassing Williamston, Pelzer, and Piedmont; the old alignment later became connector route for US 29/SC 20.

In concurrency with SC 291, it reaches Wade Hampton Boulevard; leaving behind a business loop through downtown Greenville.

In 1962, US 29 was removed from I-85 from Spartanburg to North Carolina and was moved back on its original routing, replacing US 29 Alt.