The cast reprising their roles from the web series are Laura Bailey, Taliesin Jaffe, Ashley Johnson, Liam O'Brien, Marisha Ray, Sam Riegel and Travis Willingham.
Matthew Mercer, the Dungeon Master of the campaign, also stars as Trinket, Lord Sylas Briarwood, Umbrasyl and voices a number of background characters.
[4][5][6] Vex'ahlia "Vex" Vessar (voiced by Laura Bailey), is a half-elf ranger and the twin sister of Vax'ildan.
[8][9] She is accompanied by Trinket (voiced by Matthew Mercer; Cheech Marin in Vex's Fey Realm hallucination), an armored bear companion she found as a cub and raised.
Upon returning to Syngorn as an adult, Syldor continues to dismiss both the twin's accomplishments and their quest for Fenthras, a Vestige of Divergence; Vex "defers to his anger and even chides Vax when he attempts to rebuke him".
[10] In season 3, Vex and Percy gain feelings for one another, and after a few trysts together, decide to not pursue a romantic relationship yet, but stay as "teammates with benefits".
Percival "Percy" Fredrickstein Von Musel Klossowski de Rolo III (voiced by Taliesin Jaffe) is a human gunslinger.
Along the way, Percy struggles with a dark force tied to his thirst for vengeance, manifesting in a demon called Orthax, who offers him power in exchange for his soul.
In season 3, Pike obtains the Plate of the Dawnmartyr, a special magical armor that can turn a dragon's fire attack back against them.
Vax'ildan "Vax" Vessar (voiced by Liam O'Brien) is a rogue and is the twin brother of Vex'ahlia, and their close bond is central to their characters.
Vax struggles with feelings of vulnerability and a deep fear of losing his loved ones, which motivates his fierce protectiveness toward Vex and the rest of the group.
This connection to the Matron of Death introduces a darker, more introspective side to Vax, as he grapples with the weight of his new responsibilities and his role in guiding souls to the afterlife.
[14][15] Keyleth, or "Keykey" as she's sometimes called, is initially apprehensive and doubting of her abilities, but slowly gains confidence throughout the series' first two seasons.
Madison Durham, for Polygon in 2022, wrote that "the characterization of Keyleth in the animated series is entirely consistent with how Ray played her in the show, refined and honed for this new format" and acts as "redemption" for the character.
[13] Andrea Towers, for TV Insider in 2023, wrote that "the animated series is doing something remarkable: it's opening up Keyleth to an entirely new segment of fans, both new and old, who are falling in love with her endearing nature and struggles with self-confidence and seeing her in an entirely different way than people did a few years ago.
Big enough to rescue an orphaned bear cub, fierce enough to protect her brother and her friends, and kind enough to welcome a half-sister with open arms".
[10] James Grebey, for Vulture in 2023, commented on the character design of the Chroma Conclave – "the stylistic choice to make the dragons computer generated, rather than the more traditional-looking animation of the human characters and backgrounds, sometimes sticks out, but it only makes [the Chroma Conclave's invasion of Emon] sequence even more effective.