In Uncharted: Drake's Fortune, he must stop a British crime lord and his group of South American mercenaries and Southeast Asian pirates from collecting a cursed golden idol known as "El Dorado" and using it as a biological weapon.
In Uncharted 2: Among Thieves, he races a homicidal Serbian war criminal, a British treasure hunter and his army of henchmen to find the powerful and mythical Cintamani Stone in Shambhala.
In Uncharted: a Thief's End, he and his brother Samuel Drake compete with an American businessman and a South African Private Military Company to find the fabled pirate colony of Libertalia.
He has had two love interests in the series so far; the aforementioned Elena Fisher, a reporter and now his wife, and Chloe Frazer, another treasure hunter and an old flame, but was involved with Rika Raja in the motion comic.
In Uncharted 2: Among Thieves, he is hired by an old friend named Harry Flynn to help him steal an oil lamp from a museum that might point to the location of Marco Polo's lost fleet.
[10] When Flynn betrays him, Drake sets out to stop the former's employer, warlord and war criminal Zoran Lazarević, from discovering the location of Shambhala and the mystical Cintamani Stone.
Her network has instructed her to film him while he raises the coffin of Sir Francis Drake from the bottom of the ocean, which he locates from coordinates on a family heirloom ring he wears around his neck.
[44] In Uncharted 2: Among Thieves, Frazer begins as a business associate of Drake and Harry Flynn, when a benefactor hires the group to steal an oil lamp from a Turkish museum.
While not appearing in Uncharted 4: A Thief's End, she is briefly mentioned at the start of the game, when Nathan reads a letter of hers stating that if Nate ever needs to return to treasure hunting, she is available.
The story involves notorious drug lord Hector Alcázar, who broke Samuel free and demanded half of the treasure of the Gunsway in exchange for his life being spared.
Throughout the majority of the game, he pretends to be a Hoysala expert for Asav until he is rescued by Chloe and Nadine, the latter of whom he was initially at odds with due to their last encounter in Libertalia and the fact that he and Nathan killed most of her men; he eventually partly makes amends with her.
Sam promises Nate that he will return before handing him a ring belonging to their ancestor Sir Francis Drake, with the inscription "sic parvis magna" ("greatness from small beginnings").
During the events of A Thief's End, she is the leader of the South African private military company Shoreline, and forms a partnership with Rafe Adler in finding Henry Avery's lost treasure.
It is revealed she has left Shoreline following her dispute with Rafe and subsequent betrayal by her lieutenant Orca, although she plans to retake the company once she fulfills her commitment with Frazer.
According to Naughty Dog, Cutter was originally supposed to remain by the protagonists' side until the final battle with Katherine Marlowe and Talbot, but McTavish was forced to drop out in order to fly to New Zealand after landing a role in The Hobbit.
Though never made into a chapter, there was a drafted sequence where Drake and Fisher attempt to sneak into an airship to get to an island in search of El Dorado,[54] but the area is infested by Navarro's mercenaries.
When Drake and Fisher find the room where El Dorado is supposedly located, they are followed by Raja and his last surviving pirate, running from a large number of cursed zombie-like Spaniards.
Marlowe appears to have studied Nathan's past and reveals that he's not actually a direct descendant of Sir Francis Drake; he was merely in an orphanage named after the great explorer.
Nathan eventually finds her using a winch to drag out King Solomon's hallucinogenic talisman from a lake in Ubar, and destroys the foundations of the city, causing Marlowe to fall into a pool of quicksand.
However, Guerro quickly realised that without a good source of funds, he would be unable to compete with the military strength of the new government, so he indulged in abductions and drug running to build up the cash.
He was approached by archaeologist Vincent Perez and his partner Jason Dante, who wished to investigate ruins within Guerro's territory on a potential lead to Quivira, one of the Seven Cities of Gold.
Adler is a wealthy American businessman and treasure hunter as well as an old acquaintance of the Drake brothers, working with them by infiltrating a Panamanian prison to find clues regarding the whereabouts of legendary pirate Henry Avery's lost fortune.
He comes into contact with the protagonists at an auction in Italy, subtly warning Victor Sullivan to stay out of his way, though he fails to obtain the St. Dismas Cross when it is stolen by Sam and Nate.
However, it was later revealed that Alcázar was killed in a shootout in Argentina six months prior to the current events of Uncharted 4, and Sam's story was a lie to get Nathan to help him find the treasure before Adler and Ross.
Orca later appears in Uncharted: The Lost Legacy, taking command of Shoreline after Ross departs from the company, and has struck a deal with the Indian insurgents headed by Asav.
The head of a group of Indian insurgents, he competes with Chloe and Nadine in finding the Tusk of Ganesh in India, and has captured Samuel Drake and used him as a Hoysala expert until Frazer and Ross rescue him.
He is revealed to have Shoreline, Nadine's former private military company, working with him, and later sells them the Tusk in exchange for a bomb that he plans to detonate on a train heading towards a nearby city.
He goes insane at the end of the game after his plans of sparking a civil war become compromised by Frazer, Ross and Drake's efforts in stopping the train from reaching the city.
The developers felt that the sequences involving Tenzin leading Drake through the cave systems and then seeing his village burning would create an emotionally moving experience for the player.
Thus she was instrumental in Nathan and Samuel's eventual turn to a life of exploring and treasure hunting and them adopting the Drake surname, in honor of what she and their mother believed and the fact that they could not return to their previous lives.