Littlestown Senior High School is a small, rural public high school located in Littlestown, Pennsylvania, United States.

It is part of the Littlestown Area School District.

In 2013, Littlestown Senior High School enrollment was reported at 605 pupils.

The school's colors are blue and gold, and the mascot is the Thunderbolt.

Throughout the history of Littlestown Senior High School, athletic programs have been emphasized through the years.