James Roday, Dulé Hill, Timothy Omundson, Maggie Lawson, Corbin Bernsen and Kirsten Nelson all reprise their roles as the main characters in the series.

Anthony Michael Hall reprises his role as Interim Chief Harris Trout, while Kristy Swanson, Kurt Fuller and Sage Brocklebank return as Marlowe Lassiter, Woody the Coroner and Buzz McNab, respectively.

John Kapelos also returns as Tom Swaggerty, the Mayor of Santa Barbara, for the sixth episode of the season, called "1967: A Psych Odyssey", that marks the directorial debut of Kirsten Nelson.

Using a “Guy Ritchie” style voiceover, Shawn and Gus recount being summoned to London by Interpol to take part in an undercover sting operation against ruthless criminal Ronnie Ives (Vinnie Jones).

In a video log, Shawn details not only his final case of the series, but also his decision to move to San Francisco to be with Juliet, one that he doesn't know how to divulge to Gus.

This final case involves a man (Billy Zane) suspected of murdering his business partner, which initially proves difficult to solve since Brannigan (Mira Sorvino) is outpacing Shawn at every turn.

Shawn tracks Juliet to a crime scene in San Francisco where he also reunites with Vick, and Gus has also followed him there after stealing their old high school's driver's ed car.

Shawn and Gus agree to move the Psych office to San Francisco, though Vick tells him that they already have a consultant who is busy "alphabetizing the pantry" (a deliberate reference to Adrian Monk).