[1] Lone Echo II features similar gameplay to its predecessor, revolving around zero gravity locomotion, with the player grabbing and pushing off various objects in the environment.

The gameplay is based around puzzle-solving through interaction with objects in the game world, such as cranes, doors, socketing items, holographic maps, etc.

They uncover that the biomass they encountered in Lone Echo has evolved into a mobile form called "ticks" that are attracted to energy sources.

IGN stated "Lone Echo 2 is an enjoyable space drama with striking details and fun movement mechanics, but it lacks innovation and struggles to justify its eight-hour runtime.

"[12] While enjoying the world the game was set in, Road to VR criticized the lack of challenging gameplay in the title, writing "Lone Echo II just never asks that much of you, and subsequently doesn’t ever manage to raise the level of tension".