These layers prevent any direct connectivity between the bilateral lobes of the cortex, thus requiring any tracts to pass through the corpus callosum.

[4] The corpus callosum connects the two halves of the brain below the fissure and conveys visual, auditory, and somatosensory messages between each half.

The corpus callosum is responsible for eye movement and visual perception, maintaining a balance between arousal and attention, and the ability to identify locations of sensory stimulation.

[5][6] It is thought that a majority of existing animals, including Homo sapiens, have evolved from a common wormlike ancestor that lived around 600 million years ago, called the urbilaterian.

[10] The neural tube is where the central nervous system forms, which later on in development will be subdivided and differentiated into distinct sections of the brain and spinal cord.

[11] The bilateral sides of this structure then give rise to the two hemispheres of the Homo sapiens cortex but do not merge at any point besides the corpus callosum.

[14] Stroke patients have been found to unilateral impairment following damage to either the left or right hemisphere, this effecting the opposite side of the body.

[19] These two components combined give the ability to have a larger perceived visual field, which coincides with the hypothesis that this is an adaptive function given by the fissures placement and structure.

[21] Without the presence of longitudinal fissure, the corpus callosotomy procedure would be significantly more challenging and dangerous, as it would require the surgeon to navigate through densely connected cortical areas.

[22] This is because the Fusiform Face Area (FFA) is in the right hemisphere, while language centers are predominantly in the left hemisphere.In studies, low-frequency repetitive transcranial magnetic stimulation (rTMS) applications have been tested with various cognitive processes during time perception tasks.

[23] The longitudinal fissure can serve as an effective surgical passage in the frontal bone during central and pterional craniotomies, which is opening into the skull by surgery.

[26][27] For instance, occipital-callosal fiber tracts were localized with 1–2  mm precision using DTI-TF techniques - which are very important for the cooperation of visual cortices, and any lesion to them can lead to alexia, the inability to read.