The entorhinal cortex (EC) is an area of the brain's allocortex, located in the medial temporal lobe, whose functions include being a widespread network hub for memory, navigation, and the perception of time.

[7] Recently, a general theory has been proposed to elucidate the function of the reelin positive cells in the layer II of the entorhinal cortex.

[8] This concept is underscored by the fact that fan cells of the entorhinal cortex are indispensable for the formation of episodic-like memories in rodents.

Alterations in the neural activity across the brain region results in an observed "traveling wave" phenomena across the MEC long-axis, similar to that of the hippocampus,[12] due to asymmetric theta oscillations.

[15] Lopez et al.[16] have shown, in a multimodal study, that there are differences in the volume of the left entorhinal cortex between progressing (to Alzheimer's disease) and stable mild cognitive impairment patients.

These authors also found that the volume of the left entorhinal cortex inversely correlates with the level of alpha band phase synchronization between the right anterior cingulate and temporo-occipital regions.

In 2012, neuroscientists at UCLA conducted an experiment using a virtual taxi video game connected to seven epilepsy patients with electrodes already implanted in their brains, allowing the researchers to monitor neuronal activity whenever memories were being formed.

As the researchers stimulated the nerve fibers of each of the patients' entorhinal cortex as they were learning, they were then able to better navigate themselves through various routes and recognize landmarks more quickly.