[6] It has dense reciprocal projections with the visual cortex, postsubiculum (also known as dorsal presubiculum) and with anterior thalamic nuclei and the hippocampus.

[8][9] Recent studies have shown that retrosplenial neuronal activity reflects multiple parameters simultaneously including which environment the animal is currently in,[10] its spatial position in the environment,[11][10] its current head direction and running speed,[10] as well as whether the animal is turning[11] or plans to turn in the future.

[13] In humans, fMRI studies implicate the retrosplenial cortex in a wide range of cognitive functions including episodic memory, navigation, imagining future events and processing scenes more generally.

[27] People with lesions involving the retrosplenial cortex also display a form of topographical disorientation whereby they can recognise and identify environmental landmarks, but are unable to use them to orientate themselves.

[2] The retrosplenial cortex is one of the first regions to undergo pathological changes in Alzheimer's disease and its prodromal phase of mild cognitive impairment.