[2] Lopagno, together with Cagiallo and Campestro, formed a Vicinanza since the Middle Ages.
The inhabitants of Lopagno were among the leaders of the popular uprising against the authorities of the Helvetic Republic on 26 January 1802.
Since 1952, the Institute Don Orione for the care of the mentally disabled, is active in Lopagno.
[2] The S. Apollonia chapel dates back to the 16th century, and is a dependent of the parish of Tesserete.
The village is located in the Capriasca valley at the entrance to Val Colla and includes the hamlets of Treggia, Somazzo and Oggio The historical population is given in the following chart:[2]