On 28 August 1801, i.e., before Lord Melville was built, the EIC agreed with Robert Charnock to engage her for six voyages.

[2] Lord Melville, Earl Spencer, Princess Mary, Northampton, Anna, Ann, Glory, and Essex left Rio on 13 October.

[2] EIC voyage #2 (1806–1808): Captain Lennox sailed from Portsmouth on 30 March 1806, bound for Madras and Bengal in a convoy that included Asia, Lady Burges, Lord Nelson, Sovereign, and Walthamstow, and that was under the escort of HMS Leopard.

During the night of 20 April Lady Burges wrecked on a reef off Boa Vista, Cape Verde.

Lord Melville reached Madras on 26 August, and arrived at Diamond Harbour on 30 October and Kidderpore on 14 November.

[2] EIC voyage #3 (1809–1810): Captain John Nelson Whyte acquired a letter of marque on 5 December 1808.

[2] EIC voyage #4 (1811–1812): Captain James George Crabb acquired a letter of marque on 15 March 1811.

Homeward bound she was at Saugor on 7 December, Madras on 25 January 1814, Colombo on 14 February, and the Cape on 25 April.

[2] EIC voyage #6 (1815–1816): Captain Crabb sailed from The Downs on 3 Apr 1815 bound for Madras and Bengal.